文章基本信息

标题：Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice
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作者：Jin Imai ; Takashi Yahata ; Hitoshi Ichikawa 等
期刊名称：Intestinal Research
印刷版ISSN：1598-9100
电子版ISSN：2288-1956
出版年度：2020
卷号：18
期号：2
页码：219-228
DOI：10.5217/ir.2019.00037
出版社：Korean Association for the Study of Intestinal Diseases
摘要：Background/Aims Intestinal fibrosis is a major complication of Crohn’s disease (CD). The profibrotic protein transforming growth factor-β (TGF-β) has been considered to be critical for the induction of the fibrotic program. TGF-β has the ability to induce not only the expression of extracellular matrix (ECM) including collagen, but also the production of plasminogen activator inhibitor-1 (PAI-1) that prevents enzymatic degradation of the ECM during the onset of fibrotic diseases. However, the significance of PAI-1 in the developing intestinal fibrosis has not been fully understood. In the present study, we examined the actual expression of PAI-1 in fibrotic legion of intestinal inflammation and its correlation with the abnormal ECM deposition.
关键词：Plasminogen activator inhibitor;1; Matrix metalloproteinase 9; Intestinal fibrosis; Crohn disease; 2;4;6;Trinitrobenzene sulfonic acid