文章基本信息

标题：Total Syntheses and Cytotoxic Evaluations of Cryptolactones A1, A2, B1, B2, and Their Derivatives
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作者：Makoto Inai ; Yuki Oguri ; Mitsuyo Horikawa 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2020
卷号：68
期号：4
页码：380-383
DOI：10.1248/cpb.c19-01114
出版社：The Pharmaceutical Society of Japan
摘要：The cryptolactones A 1 , A 2, B 1 , and B 2 isolated from a Cryptomyzus sp. aphid were synthesized via the Mukaiyama aldol reaction and olefin metathesis. Their antipodes and derivatives were also synthesized by the same strategy to investigate structure–activity relationships. These compounds exhibited cytotoxic activity against human promyelocytic leukemia HL-60 cells with IC 50 values of 2.1–42 µM..
关键词：cryptolactones;asymmetric synthesis;cytotoxicity