文章基本信息

标题：G2G: A web-server for the prediction of human synthetic lethal interactions
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作者：Yom Tov Almozlino ; Iftah Peretz ; Martin Kupiec 等
期刊名称：Computational and Structural Biotechnology Journal
印刷版ISSN：2001-0370
出版年度：2020
卷号：18
页码：1028-1031
DOI：10.1016/j.csbj.2020.04.012
出版社：Computational and Structural Biotechnology Journal
摘要：Genetic interactions (GIs) are fundamental to our understanding of biological processes in the cell. While GIs have been systematically mapped in yeast, there is scarce information about them in humans. Recently, we have suggested a state-of-the-art hierarchical method that leverages gene ontology information for predicting GIs in yeast. Here, we adapt this method and apply it for the first time to predict GIs in human. We introduce a web service called G2G for this task that is available at http://bnet.cs.tau.ac.il/g2g/ .