文章基本信息

标题：Methylparaben in meconium and risk of maternal thyroid dysfunction, adverse birth outcomes, and Attention-Deficit Hyperactivity Disorder (ADHD)
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作者：Brennan H. Baker ; Haotian Wu ; Hannah E. Laue 等
期刊名称：Environment International
印刷版ISSN：0160-4120
电子版ISSN：1873-6750
出版年度：2020
卷号：139
页码：1-7
DOI：10.1016/j.envint.2020.105716
出版社：Pergamon
摘要：Background Parabens, which are used as a preservative in foods and personal care products, are detected in nearly 100% of human urine samples. Exposure to parabens is associated with DNA damage, male infertility, and endocrine disruption in adults, but the effects of prenatal exposure are unclear. In part, this is due to inadequate assessment of exposure in maternal urine, which may only reflect maternal rather than fetal exposure. To address this gap, we examined the association of prenatal methylparaben measured in meconium with preterm birth, gestational age, birthweight, maternal thyroid hormones, and child Attention-Deficit Hyperactivity Disorder (ADHD) at 6–7 years.
关键词：Attention-Deficit Hyperactivity Disorder (ADHD) ; Birth outcomes ; Thyroid hormones ; Endocrine disruption ; Prenatal exposure ; Parabens