文章基本信息

标题：Effects of medicinal plant ipe on expression of inducible nitric oxide synthase in inerleukin-1β-stimulated Hepatocytes
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作者：Takashi Ozaki ; Yusai Kawaguchi ; Masaya Kotsuka 等
期刊名称：Functional Foods in Health and Disease
电子版ISSN：2160-3855
出版年度：2019
卷号：9
期号：10
页码：648-661
DOI：10.31989/fhd.v9i 10.650
出版社：Food Science Publisher
摘要：Background: The traditional medicine ipe is thought to have various pharmacological actions including anticancer and anti-inflammatory activities.However,there is little scientific evidence to demonstrate the organ-protective effects of ipe.The prevention of nitric oxide (NO)production in inflamed livers by inducible NO synthase (iNOS) is an indicator of liver protection.We examined proinflammatory cytokine-stimulated hepatocytes as a simple“in vitro liver injury model”to determine ipe's liver-protective effects of ipe and clarify its mechanisms. This study aims to examine whether ipe influences iNOS induction and NO production，and if so，the mechanisms involved in its action.
关键词：ipe;induciblenitric oxide synthase,liver injury,primary cultured hepatocytes,nuclearfactor-KB,the type I interleukin-1 receptor,iNOS antisense transcript