文章基本信息

标题：Comparison of Age and Gender Differences of Tryptophan Metabolites in Patients of Major Monopolar and Bipolar Depression
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作者：Hiroi Tomioka ; Junichi Masuda ; Akikazu Takada 等
期刊名称：Food and Nutrition Sciences
印刷版ISSN：2157-944X
电子版ISSN：2157-9458
出版年度：2020
卷号：11
期号：3
页码：172-185
DOI：10.4236/fns.2020.113013
出版社：Scientific Research Publishing
摘要：Background: No research has been done for the determination of plasma levels of tryptophan metabolites in patients of monopolar and bipolar depression. Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: No significant age and gender differences were shown in monopolar depressive patients and some differences were shown in bipolar patients. The administration of drugs such as antidepressants, antipsychotics, mood stabilizers do not seem to have affected the results. Conclusion: In patients of major monopolar depression age and gender differences of plasma levels of tryptophan metabolites disappear although significant differences are observed in healthy volunteers. Some differences of age and gender differences were shown between monopolar and bipolar depressive patients.
关键词：Depression;Monopolar Depression;Bipolar Depression;Tryptophan;Serotonin;5;Hydroxyindole Acetic Acid;Kynurenine;3;Hydroxykynurenine;Kynurenic Acid;Anthranilic Acid;Xanthurenic Acid;Indole;3;Acetic Acid;SSRI (Selective Serotonin Reuptake Inhibitor);SNRI (Serotonin Norepinephrine Reuptake Inhibitor);Anxiolytic;Antipsychotic