文章基本信息

标题：MicroRNAs as Biomarkers and Therapeutic Targets in Heart Failure
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作者：István Adorján Szabó ; Atilla Frigy
期刊名称：Acta Medica Marisiensis
电子版ISSN：2247-6113
出版年度：2019
卷号：65
期号：3
页码：77-79
DOI：10.2478/amma-2019-0016
出版社：Walter de Gruyter GmbH
摘要：Heart failure still represents a real challenge both in everyday practice and research, due to the complex issues related to its pathogenesis and management. Humoral biomarkers have emerged in the last decades as useful tools in the diagnosis, risk stratification and guiding the treatment of heart failure. These molecules are related to different pathological and adaptive processes, like myocardial injury, neurohormonal activation and cardiac remodeling, their most widespread representatives being the natriuretic peptides (e.g. NT-proBNP). The role of altered gene expression and transcription as the basis of myocardial structural and functional changes in heart failure is largely recognized. MicroRNAs (miRNAs) are non-coding RNAs which have a major role in post-transcriptional gene expression by interfering with messenger RNA molecules. Our short review summarizes the molecular biology of miRNAs and their possible role as biomarkers in the diagnosis and prognosis of heart failure. Furthermore, the therapeutical perspectives conferred by these molecules are also presented..
关键词：miRNA ; biomarkers ; heart failure