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标题：Mitigation of Memory Impairment in Ovariectomized Rats Using Garlic Powder Treated with Subcritical Water
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作者：Akira Minami ; Yasuyo Mikami ; Takahiro Kano 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2020
卷号：43
期号：3
页码：546-549
DOI：10.1248/bpb.b19-00311
出版社：The Pharmaceutical Society of Japan
摘要：Women with estrogen deficiency are at the risk of suffering from neurological symptoms such as memory impairment. In the present study, we investigated the effect of garlic, Allium sativum L. (Asparagales: Amaryllidaceae), treated with subcritical water on memory impairment in ovariectomized (OVX) rats. OVX rats were administered garlic powder for 84 d. Hippocampus-dependent spatial memory was assessed using the Morris water maze test. Escape latency of the OVX rats increased compared with that of sham-operated rats. The prolonged escape latency of the OVX rats decreased to the level of that of sham-operated rats upon the administration of garlic powder (0.5% in feed). The weights of the body, uterus, and brain were not affected by the garlic powder administration. These results suggest that garlic powder treated with subcritical water mitigates memory impairment in OVX rats..
关键词：garlic;subcritical water;memory impairment;depression;rat;postmenopausal syndrome