文章基本信息

标题：Tendencias actuales en la determinación analítica de vitamina D
其他标题：Current trends in the analytical determination of vitamin D
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作者：Vázquez-Lorente, Héctor ; Herrera-Quintana, Lourdes ; Molina-López, Jorge 等
期刊名称：Nutrición Hospitalaria
印刷版ISSN：0212-1611
出版年度：2019
卷号：36
期号：6
页码：1418-1423
DOI：10.20960/nh.02713
出版社：Aula Médica Ediciones
摘要：Vitamin D is a micronutrient that plays a large role in bone disease, and researchers are now discovering that it also does so in non-skeletal disease, thus making high-quality analytical determination necessary. To make this determination, a series of immunochemical and physical methods are used. These methods present a series of different ways of handling samples as well as different methodologies that bring a series of advantages and limitations based on the scope of work in which the vitamin D analysis methodology is applied. Although the Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) is the gold standard method of analytical vitamin D determination, and is the only one to offer a more complete and accurate view of all metabolites of this vitamin, it is necessary to standardize all the analysis methodologies that allow accurate, reliable and quality analytical determination, since it is essential to obtain results that can reliably be extrapolated to the population, and that can be decisive in assessing a large number of pathologies..
关键词：Cromatografía líquida;espectrometría de masas en tándem (LC;MS;MS);Vitamina D;Inmunoensayo;Cromatografía;Estandarización
其他关键词：Liquid chromatography-tandem Mass Spectrometry (LC-MS/MS);Vitamin D;Inmunoassay;Chromatography;Standardization