文章基本信息

标题：Inhaled nicotine and lung cancer: Potential role of the nicotinic acetylcholine receptor
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作者：R. P. Young ; R. J. Scott
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2020
卷号：117
期号：9
页码：4460-4461
DOI：10.1073/pnas.1921567117
出版社：The National Academy of Sciences of the United States of America
摘要：The article by Tang et al. (1) shows electronic-cigarette smoke (ECS) causes lung cancer and bladder hyperplasia in mice. Tang et al. (1) should be congratulated for their research contributing to this body of work, raising concerns about the effect of ECS on the lungs (1, 2). We outline below why we think nicotine may be directly carcinogenic when inhaled into the lungs and how this would explain why low levels of nitrosamines provide no comfort with regard to the safety of ECS (1). Tang et al. (1) make important findings in this and earlier work (1, 2). First, lung cancer developed in the mice inhaling nicotine mixed with vehicle but not vehicle alone.