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  • 标题:The size of the immune repertoire of bacteria
  • 本地全文:下载
  • 作者:Serena Bradde ; Armita Nourmohammad ; Sidhartha Goyal
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2020
  • 卷号:117
  • 期号:10
  • 页码:5144-5151
  • DOI:10.1073/pnas.1903666117
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Some bacteria and archaea possess an immune system, based on the CRISPR-Cas mechanism, that confers adaptive immunity against viruses. In such species, individual prokaryotes maintain cassettes of viral DNA elements called spacers as a memory of past infections. Typically, the cassettes contain several dozen expressed spacers. Given that bacteria can have very large genomes and since having more spacers should confer a better memory, it is puzzling that so little genetic space would be devoted by prokaryotes to their adaptive immune systems. Here, assuming that CRISPR functions as a long-term memory-based defense against a diverse landscape of viral species, we identify a fundamental tradeoff between the amount of immune memory and effectiveness of response to a given threat. This tradeoff implies an optimal size for the prokaryotic immune repertoire in the observational range..
  • 关键词:CRISPR;Cas ; adaptive immunity ; bacteria ; phage ; optimal memory
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