文章基本信息

标题：Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells
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作者：Rene Barro-Soria ; Alejandro Caicedo ; Herbert Jägle 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2019
卷号：9
期号：1
页码：1-16
DOI：10.1038/s41598-019-55380-8
出版社：Springer Nature
摘要：Fast, precise and sustained neurotransmission requires graded Ca 2+ signals at the presynaptic terminal. Neurotransmitter release depends on a complex interplay of Ca 2+ fluxes and Ca 2+ buffering in the presynaptic terminal that is not fully understood. Here, we show that the angiotensin-receptor-associated protein (ATRAP) localizes to synaptic terminals throughout the central nervous system. In the retinal photoreceptor synapse and the cerebellar mossy fiber-granule cell synapse, we find that ATRAP is involved in the generation of depolarization-evoked synaptic Ca 2+ transients. Compared to wild type, Ca 2+ imaging in acutely isolated preparations of the retina and the cerebellum from ATRAP knockout mice reveals a significant reduction of the sarcoendoplasmic reticulum (SR) Ca 2+ -ATPase (SERCA) activity. Thus, in addition to its conventional role in angiotensin signaling, ATRAP also modulates presynaptic Ca 2+ signaling within the central nervous system.