文章基本信息

标题：Green Synthesis of Substituted Anilines and Quinazolines from Isatoic Anhydride-8-amide
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作者：Sudershan R. Gondi ; Asim K. Bera ; Kenneth D. Westover 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2019
卷号：9
期号：1
页码：1-23
DOI：10.1038/s41598-019-50776-y
出版社：Springer Nature
摘要：Synthetic methods used to generate substituted anilines and quinazolines, both privileged pharmacological structures, are cumbersome, hazardous or, in some cases, unavailable. We developed a straightforward method for making isatoic anhydride-8-amide from isatin-7-carboxylic acid as a tool to easily produce a range of quinazoline and substituted aniline derivatives using adaptable pH-sensitive cyclization chemistry. The approaches are inexpensive, simple, fast, efficient at room temperature and scalable, enabling the synthesis of both established and new quinazolines and also highly substituted anilines including cyano derivatives.