文章基本信息

标题：Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake
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作者：Javier I. Ottaviani ; Reedmond Fong ; Jennifer Kimball 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2019
卷号：9
期号：1
页码：1-10
DOI：10.1038/s41598-019-49702-z
出版社：Springer Nature
摘要：Data from dietary intervention studies suggest that intake of (-)-epicatechin mediates beneficial vascular effects in humans. However, population-based investigations are required to evaluate associations between habitual intake and health and these studies rely on accurate estimates of intake, which nutritional biomarkers can provide. Here, we evaluate a series of structurally related (-)-epicatechin metabolites (SREM), particularly (-)-epicatechin-3'-glucuronide, (-)-epicatechin-3'-sulfate and 3'-O-methyl-(-)-epicatechin-5-sulfate (SREM B ), as flavan-3-ol and (-)-epicatechin intake. SREM B in urine proved to be a specific indicator of (-)-epicatechin intake, showing also a strong correlation with the amount of (-)-epicatechin ingested (R 2 : 0.86 (95% CI 0.8l; 0.92). The median recovery of (-)-epicatechin as SREM B in 24 h urine was 10% (IQR 7-13%) and we found SREM B in the majority of participants of EPIC Norfolk (83% of 24,341) with a mean concentration of 2.4 ± 3.2 µmol/L. Our results show that SREM B are suitable as biomarker of (-)-epicatechin intake. According to evaluation criteria from IARC and the Institute of Medicine, the results obtained support use of SREM B as a recovery biomarker to estimate actual intake of (-)-epicatechin.