文章基本信息

标题：Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer’s disease
本地全文：下载
作者：Udaysankar Chockanathan ; Emily J. Warner ; Loel Turpin 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2020
卷号：10
期号：1
页码：1-12
DOI：10.1038/s41598-020-58038-y
出版社：Springer Nature
摘要：While the link between amyloid β (Aβ) accumulation and synaptic degradation in Alzheimer's disease (AD) is known, the consequences of this pathology on population coding remain unknown. We found that the entropy, a measure of the diversity of network firing patterns, was lower in the dorsal CA1 region in the APP/PS1 mouse model of Aβ pathology, relative to controls, thereby reducing the population's coding capacity. Our results reveal a network level signature of the deficits Aβ accumulation causes to the computations performed by neural circuits.