文章基本信息

标题：Curcumin A Potential Antagonist Against Paracetamol Induced Nephrotoxicity in Rats -
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作者：Manal R. Ibrahim Nabil M. Taha Abd El-Wahab Mandour Mohamed A. Lebda Aml E. Hashem
期刊名称：Alexandria Journal of Veterinary Sciences
印刷版ISSN：1110-2047
电子版ISSN：1110-2047
出版年度：2019
卷号：62
期号：2
页码：37-44
DOI：10.5455/ajvs.58645
出版社：International Medical Journal Management and Indexing System
摘要：Paracetamol can cause a life threating renal damage and there is no specific treatment for it. Therefore, the current study aims to investigate the nepheroprotective effect of curcumin against paracetamol nephrotoxicity in rats through determination of kidney function parameters, minerals concentration, kidney lipid peroxidation and antioxidants. To achieve this aim, seventy adult male albino rats were divided into equal seven groups as following, Group I served as control,Group II (corn oil treated group), Group III (curcumin200 mg/kg b.wt/orally), Group IV (Curcumin 400 mg/kg b.wt/orally), Group V served as positive control (Paracetamol 500 mg/kg b.wt/orally), Group VI (Curcumin 200 mg/kg b.wt and paracetamol 500 mg/kg b.wt/orally), and Group VII (Curcumin 400 mg/kg b.w and paracetamol 500 mg/kg b.w/orally). At the end of experiment (after 30 days), blood and tissue samples were collected for biochemical, and histopathological analysis.
关键词：Renal toxicity; Curcumin; Paracetamol;Rats.