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标题：Potential Protective Effect of Curcumin on Paracetamol Model of Liver Injury in Rats -
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作者：Rania A. Sedky Nabil M. Taha Abd El-Wahab Mandour Mohamed A. Lebda Aml E. Hashem
期刊名称：Alexandria Journal of Veterinary Sciences
印刷版ISSN：1110-2047
电子版ISSN：1110-2047
出版年度：2019
卷号：63
期号：1
页码：77-84
DOI：10.5455/ajvs.63350
出版社：International Medical Journal Management and Indexing System
摘要：Objective The objective of the this study is to investigate the protective effect of curcumin on paracetamol induced hepatotoxicity in rats through determination of, serum protein concentration, ammonia, bilirubin, liver enzymes activities, liver lipid peroxidation and antioxidants. The study was carried on 70 male rats weighing 140± 10 divided into equal 7 groups as following: GI: control, GII: control corn, GIII: curcumin (200mg/kgb.wt/gavage), GIV: curcumin (400mg/kgb.wt/gavage), GV: paracetamol (500mg/kgb.wt/gavage), GVI: Curcumin (200mg/kgb.wt/gavage) + paracetamol (500mg/kgb.wt/gavage) and GVII: curcumin (400mg/kgb.wt/ gavage)+ paracetamol (500mg/kgb.wt/ gavage). After 30 days, blood was collected for biochemical examination. Results: Paracetamol at dose (500 mg/kg b.wt) caused marked liver damage as there was pronounced increase in bilirubin, ammonia and MDA levels along with marked elevation in liver enzyme activities while levels of serum proteins, GSH and Catalase activity markedly decreased. Interestingly, curcumin was able to ameliorate hepatic deterioration caused by paracetamol via restoring depleted glutathione, rebalanced antioxidants and improved damage as curcumin (200 mg/ kg b.wt) successfully decreased degree of hepatic vacuolation with best improvent via curcumin (400 mg/ kg b.wt). Conclusion: Curcumin showed protective effect on paracetamol induced hepatotoxicity as it successfully improved the altered hepatic parameters and through its powerful antioxidant properties.
关键词：Keywords;Hepatotoxicity; paracetamol; curcumin; antioxidant.