文章基本信息

标题：Global properties of saturated chikungunya virus dynamics models with cellular infection and delays
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作者：A. M. Elaiw ; S. E. Almalki ; A. D. Hobiny 等
期刊名称：Advances in Difference Equations
印刷版ISSN：1687-1839
电子版ISSN：1687-1847
出版年度：2019
卷号：2019
期号：1
页码：1-33
DOI：10.1186/s13662-019-2409-5
出版社：Hindawi Publishing Corporation
摘要：This paper studies the global properties of chikungunya virus (CHIKV) dynamics models with both CHIKV-to-monocytes and infected-to-monocyte transmissions. We assume that the infection rate of modeling CHIKV infection is given by saturated mass action. The effect of antibody immune response on the virus dynamics is modeled. The models included three types of time delays, discrete or distributed. The first type of delay is the time between CHIKV entry an uninfected monocyte to be latently infected monocyte. The second time delay is the time between CHIKV entry an uninfected monocyte and the emission of immature CHIKV. The third time delay represents the CHIKV’s maturation time. Lyapunov method is utilized and LaSalle’s invariance principle is applied to address the global stability of equilibria. The model is numerically simulated to support theoretical results.
关键词：Chikungunya infection ; Global stability ; Lyapunov function ; Time delay ; Latency ;