文章基本信息

标题：Case report: Successful induction of buprenorphine/naloxone using a microdosing schedule and assertive outreach
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作者：Jennifer Rozylo ; Keren Mitchell ; Mohammadali Nikoo 等
期刊名称：Addiction Science & Clinical Practice
电子版ISSN：1940-0640
出版年度：2020
卷号：15
期号：1
页码：1-6
DOI：10.1186/s13722-020-0177-x
出版社：BioMed Central
摘要：The requirement for moderate withdrawal prior to initiation can be a barrier to buprenorphine/naloxone induction. We aimed to use a microdosing regimen to initiate regular dosing of buprenorphine/naloxone in a high-risk patient with a history of failed initiations due, in part, to withdrawal symptoms. Using an assertive outreach model and a buprenorphine/naloxone microdosing schedule, we initiated treatment of an individual’s opioid use disorder. There was a successful buprenorphine/naloxone microdosing induction as the team reached a therapeutic dose of buprenorphine/naloxone. Including the induction period, the medication was used consistently for 4 weeks. A microdosing schedule can be used to induce a patient onto buprenorphine/naloxone with no apparent withdrawal; gradually reducing illicit substance use. This case report builds on previous literature, highlighting ways to minimize barriers to induction of buprenorphine/naloxone, using a microdosing schedule and assertive outreach. Given the safety profile of buprenorphine and its potential to be a lifesaving intervention, a larger study of microdosing is indicated..
关键词：Opioid use disorder ; Buprenorphine;naloxone ; Microdosing ; Bernese method ; Induction method