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标题：Association of Intake Folate and Related Gene Polymorphisms with Breast Cancer
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作者：Xiang CHEN ; Hadji AHAMADA ; Ting ZHANG 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2019
卷号：65
期号：6
页码：459-469
DOI：10.3177/jnsv.65.459
出版社：Center for Academic Publications Japan
摘要：Breast cancer is one of the most common malignancies in women worldwide and is associated with a variety of risk factors. Folate and vitamin B 12 are key elements of the one-carbon metabolism pathway where methylenetetrahydrofolate reductase (MTHFR) plays a significant role. Though many molecular and epidemiological studies have been performed to explore the relationship between intake folate, vitamin B 12 , MTHFR gene polymorphism and breast cancer risk, there is no consensus to date. By reviewing the relevant literatures and summarizing the potential effect of dietary folate intake on MTHFR genes polymorphism and breast cancer risk, we conclude that MTHFR C677T gene polymorphism is associated with breast cancer risk among Asian, but not Caucasians, and the MTHFR A1298C gene polymorphism is not a susceptibility factor of breast cancers. Concomitant low activity of MTHFR enzyme resulted from C677T gene polymorphism and low dietary folate intake is associated with increased breast cancer risk..
关键词：vitamin B9;MTHFR genes polymorphism;one;carbon metabolism pathway;DNA methylation;malignancies