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标题：D-Allose, a Stereoisomer of D-Glucose, Extends the Lifespan of Caenorhabditis elegans via Sirtuin and Insulin Signaling
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作者：Tomoya Shintani ; Hirofumi Sakoguchi ; Akihide Yoshihara 等
期刊名称：Journal of Applied Glycoscience
印刷版ISSN：1344-7882
电子版ISSN：1880-7291
出版年度：2019
卷号：66
期号：4
页码：139-142
DOI：10.5458/jag.jag.JAG-2019_0010
出版社：The Japanese Society of Applied Glycoscience
摘要：D-Allose (D-All), C-3 epimer of D-glucose, is a rare sugar known to suppress reactive oxygen species generation and prevent hypertension. We previously reported that D-allulose, a structural isomer of D-All, prolongs the lifespan of the nematode Caenorhabditis elegans . Thus, D-All was predicted to affect longevity. In this study, we provide the first empirical evidence that D-All extends the lifespan of C. elegans . Lifespan assays revealed that a lifespan extension was induced by 28 mM D-All. In particular, a lifespan extension of 23.8 % was achieved ( p < 0.0001). We further revealed that the effects of D-All on lifespan were dependent on the insulin gene daf-16 and the longevity gene sir-2.1 , indicating a distinct mechanism from those of other hexoses, such as D-allulose, with previously reported antiaging effects..
关键词：anti;aging;daf;16;sir;2.1;Caenorhabditis elegans;D;allose;lifespan