文章基本信息

标题：Aerobic Intramolecular Oxidative Coupling Using Heterogeneous Catalyst for Synthesis of N-Substituted 2,3,6,7-Tetramethoxycarbazoles
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作者：Kenji Matsumoto ; Yoshinori Kobayashi ; Tsukasa Hirokane 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2020
卷号：68
期号：2
页码：167-172
DOI：10.1248/cpb.c19-00947
出版社：The Pharmaceutical Society of Japan
摘要：A heterogeneous metal catalyst enabled the intramolecular oxidative coupling of diarylamines to form carbazoles with molecular oxygen as the sole oxidant. Rh/C had efficient catalytic activity and allowed the catalyst loading to be reduced to 0.1 mol% while maintaining excellent yields of carbazoles. This reaction is operationally simple in an open-to-air setup, and provides a green and atom-economical process for an efficient synthetic approach to N -substituted carbazoles..
关键词：heterogeneous catalyst;carbazole;oxidative coupling;aerobic oxidation;rhodium;aryl amine