文章基本信息

标题：Role of Sphingomyelinase in the Pathogenesis of Bacillus cereus Infection
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作者：Masataka Oda ; Atsushi Yokotani ; Naoki Hayashi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2020
卷号：43
期号：2
页码：250-253
DOI：10.1248/bpb.b19-00762
出版社：The Pharmaceutical Society of Japan
摘要：Bacillus cereus is well known as a causative agent of food poisoning but it also causes bacteremia and endophthalmitis in nosocomial infections. However, as an environmental bacterium that lives in soil, it is often treated as simple contamination by hospitals. In recent years, highly pathogenic B. cereus strains that are similar to Bacillus anthracis have been detected in hospitals. The B. cereus sphingomyelinase contributes to its pathogenicity, as do sphingomyelinases produced by Staphylococcus aureus , Pseudomonas aeruginosa , Helicobacter pylori , and B. anthracis . Highly pathogenic B. cereus produces a large amount of sphingomyelinase. In this review, we describe the regulation of sphingomyelinase expression through the PlcR–PapR system, the pathogenicity of bacterial sphingomyelinases, and their potential as therapeutic drug targets..
关键词：Bacillus cereus;sphingomyelinase;PlcR;PapR;nosocomial infection