文章基本信息

标题：Engineered Bacteriophages for Practical Applications
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作者：Javier Pizarro-Bauerle ; Hiroki Ando
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2020
卷号：43
期号：2
页码：240-249
DOI：10.1248/bpb.b19-00914
出版社：The Pharmaceutical Society of Japan
摘要：The diversity of advanced genetic engineering techniques that have become available in recent years has enabled a more precise manipulation of genes and genomes. Among these, bacteriophage genomes stand out as an interesting target due to their dependence on a host for replication, which previously complicated their manipulation, and due as well to the many possible fields in which they can be used. In this review, we highlight recent applications for which genetically modified bacteriophages are being employed: as phage therapy in medicine, animal industries and agricultural settings; as a source of new antimicrobials; as biosensors for research, health and environmental purposes; and as genetic engineering tools themselves..
关键词：bacteriophage;synthetic biology;phage therapy;biosensor;directed;evolution