文章基本信息

标题：Vaccines and Protective Immune Memory against Cryptococcosis
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作者：Keigo Ueno ; Nao Yanagihara ; Kiminori Shimizu 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2020
卷号：43
期号：2
页码：230-239
DOI：10.1248/bpb.b19-00841
出版社：The Pharmaceutical Society of Japan
摘要：Cryptococcosis is a potentially lethal disease caused by fungal pathogens including Cryptococcus neoformans and Cryptococcus gattii species complex. These fungal pathogens live in the environment and are associated with certain tree species and bird droppings. This infectious disease is not contagious, and healthy individuals may contract cryptococcal infections by inhaling the airborne pathogens from the environment. Although cleaning a contaminated environment is a feasible approach to control environmental fungal pathogens, prophylactic immunization is also considered a promising method to regulate cryptococcal infections. We review the history of the development of cryptococcal vaccines, vaccine components, and the various forms of immune memory induced by cryptococcal vaccines..
关键词：antifungal vaccine;dendritic cell;based vaccine;memory T cell;lung;resident memory T cell;innate immune memory;cryptococcosis