文章基本信息

标题：Emergence of Extensively Drug-Resistant Salmonella Typhi Infections Among Travelers to or from Pakistan — United States, 2016–2018
本地全文：下载
作者：Kevin Chatham-Stephens, ; Felicita Medalla, ; Michael Hughes, MPH 等
期刊名称：Morbidity and Mortality Weekly Report
出版年度：2019
卷号：68
期号：1
页码：11-13
DOI：10.15585/mmwr.mm6801a3
出版社：Centers for Disease Control and Prevention
摘要：What is already known about this topic? Extensively drug-resistant (XDR) Salmonella Typhi causing a typhoid fever outbreak in Pakistan is susceptible only to azithromycin and carbapenems. What is added by this report? During 2006–2015, 79% of U.S. isolates from typhoid fever patients who traveled to Pakistan were fluoroquinolone nonsusceptible. During 2016–2018, typhoid fever was diagnosed in 29 U.S. patients with recent Pakistan travel; five had XDR Typhi. What are the implications for public health practice? Vaccination can help prevent typhoid fever. Fluoroquinolones should not be used for empiric treatment of typhoid fever patients who traveled to South Asia. Patients with travel to Pakistan should be treated with azithromycin for uncomplicated typhoid fever and with carbapenems for complicated disease.
关键词：Extensively Drug;Resistant Salmonella Typhi; Typhoid Fever Outbreak In Pakistan; Typhoid Fever And azithromycin; Typhoid Fever And Carbapenems; MMWR; Morbidity & Mortality Weekly Report