文章基本信息

标题：Modulatory Effects of Casimiroa Edulis on Aluminium Nanoparticles -Associated Neurotoxicity in A Rat Model of Induced Alzheimer's Disease
本地全文：下载
作者：H.F. Aly ; N. S. Elrigal ; S. A. Ali 等
期刊名称：Journal of Materials and Environmental Science
印刷版ISSN：2028-2508
出版年度：2018
卷号：9
期号：7
页码：1931-1941
出版社：University of Mohammed Premier Oujda
摘要：This study evaluated the biological effectiveness of aluminum oxide nanoparticles(Al2O3NPs), on brain rats by analyzing brain function neurotransmitters, oxidative stress andantioxidant biomarkers. Rats were administered Al2O3 nanoparticles (NPs)of 20 nmdiameter at dose 50 mg/kg body weight and examined for induction of Alzheimer's disease(AD) in rats model through determination of acetylcholine esterase (ACHE), noradrenaline(NA), adrenaline (A), serotonin , dopamine , apoptotic markers; caspase -3, oxidative stress,lipid peroxide (MDA), nitric oxide (NO) antioxidant markers , glutathione reduced (GSH),total antioxidant capacity (TAC) and calmoduline (CaM) . Exposure to Al2O3 NPs inducedAD in rats showed significant reduction in NA, A with percentages decrease 42.18 and34.09%, respectively , while significant increase in ACHE activity (64.83%), as compared tonormal control rats. However AD induced rats showed significant reduction in serotonin anddopamine with percentages decrease 38.17and 54.02%, respectively as compared to normalcontrol rats. However, Al NPS intoxicated rats showed significant increase in caspase -3 withpercentages increase 99.10%. However, Al NPS induced rats showed significant decrease inTAC and GSH levels with percentages 59.70 and 61.00%, respectively. While, significantincrease in CaM(+206.09%), lipid peroxide (108.74%) and NO (74.43%) levels as comparedto normal control rats was detected. Histopathological investigation of NPs induced rats’demonstrated marked amelioration in all parameters under investigation upon treatedintoxicated rats with Casimiroa edulis total extract as compared to dopenzil standard drug.These results are conformed by histopathological examination which revealed improvementin brain neuron architectures with various degrees. It could be concluded that Casimiroaedulis total extract may be useful in ameliorating Al NPs induced AD in rats' model whichmay be used as an intelligent candidate nutraceutical.
关键词：Inflammatory markers; Neurotoxicity; Aluminum toxicity; apoptotic markers; Casimiroa edulis