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  • 标题:The Detection of Wound Infection by Ion Mobility Chemical Analysis
  • 本地全文:下载
  • 作者:Emma Daulton , Alfian Wicaksono , Janak Bechar , James A. Covington ; Joseph Hardwicke
  • 期刊名称:Biosensors
  • 电子版ISSN:2079-6374
  • 出版年度:2020
  • 卷号:10
  • 期号:3
  • DOI:10.3390/bios10030019
  • 出版社:MDPI Publishing
  • 摘要:Surgical site infection represents a large burden of care in the National Health Service. Current methods for diagnosis include a subjective clinical assessment and wound swab culture that may take several days to return a result. Both techniques are potentially unreliable and result in delays in using targeted antibiotics. Volatile organic compounds (VOCs) are produced by micro-organisms such as those present in an infected wound. This study describes the use of a device to differentiate VOCs produced by an infected wound vs. colonised wound. Malodourous wound dressings were collected from patients, these were a mix of post-operative wounds and vascular leg ulcers. Wound microbiology swabs were taken and antibiotics commenced as clinically appropriate. A control group of soiled, but not malodorous wound dressings were collected from patients who had a split skin graft (SSG) donor site. The analyser used was a G.A.S. GC-IMS. The results from the samples had a sensitivity of 100% and a specificity of 88%, with a positive predictive value of 90%. An area under the curve (AUC) of 91% demonstrates an excellent ability to discriminate those with an infected wound from those without. VOC detection using GC-IMS has the potential to serve as a diagnostic tool for the differentiation of infected and non-infected wounds and facilitate the treatment of wound infections that is cost effective, non-invasive, acceptable to patients, portable, and reliable.
  • 关键词:wound infection; gas analysis; diagnosis; VOC; GC-IMS;wound infection ; gas analysis ; diagnosis ; VOC ; GC-IMS.
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