文章基本信息

标题：Global shape of Toll activation is determined by wntD enhancer properties
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作者：Neta Rahimi ; Shari Carmon ; Inna Averbukh 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2020
卷号：117
期号：3
页码：1552-1558
DOI：10.1073/pnas.1918268117
出版社：The National Academy of Sciences of the United States of America
摘要：Buffering variability in morphogen distribution is essential for reproducible patterning. A theoretically proposed class of mechanisms, termed “distal pinning,” achieves robustness by combining local sensing of morphogen levels with global modulation of gradient spread. Here, we demonstrate a critical role for morphogen sensing by a gene enhancer, which ultimately determines the final global distribution of the morphogen and enables reproducible patterning. Specifically, we show that, while the pattern of Toll activation in the early Drosophila embryo is robust to gene dosage of its locally produced regulator, WntD, it is sensitive to a single-nucleotide change in the wntD enhancer. Thus, enhancer properties of locally produced WntD directly impinge on the global morphogen profile.
关键词：morphogen gradients ; embryogenesis ; integral feedback ; Drosophila ; Toll signaling