文章基本信息

标题：Role of lipid transporters in fungal physiology and pathogenicity
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作者：Juliana Rizzo ; Lyubomir Dimitrov Stanchev ; Vanessa K.A. da Silva 等
期刊名称：Computational and Structural Biotechnology Journal
印刷版ISSN：2001-0370
出版年度：2019
卷号：17
页码：1278-1289
DOI：10.1016/j.csbj.2019.09.001
出版社：Computational and Structural Biotechnology Journal
摘要：The fungal cell wall and membrane are the most common targets of antifungal agents, but the potential of membrane lipid organization in regulating drug-target interactions has yet to be investigated. Energy-dependent lipid transporters have been recently associated with virulence and drug resistance in many pathogenic fungi. To illustrate this view, we discuss (i) the structural and biological aspects of ATP-driven lipid transporters, comprising P-type ATPases and ATP-binding cassette transporters, (ii) the role of these transporters in fungal physiology and virulence, and (iii) the potential of lipid transporters as targets for the development of novel antifungals. These recent observations indicate that the lipid-trafficking machinery in fungi is a promising target for studies on physiology, pathogenesis and drug development.
关键词：Flippases ; ABC transporters ; Fungal infections ; Antifungals ; Phosphatidylserine ; Phosphatidylethanolamine ; Sterols