文章基本信息

标题：Keratinocyte-intrinsic MHCII expression controls microbiota-induced Th1 cell responses
本地全文：下载
作者：Samira Tamoutounour ; Seong-Ji Han ; Julie Deckers 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2019
卷号：116
期号：47
页码：23643-23652
DOI：10.1073/pnas.1912432116
出版社：The National Academy of Sciences of the United States of America
摘要：The cross-talk between the microbiota and the immune system plays a fundamental role in the control of host physiology. However, the tissue-specific factors controlling this dialogue remain poorly understood. Here we demonstrate that T cell responses to commensal colonization are associated with the development of organized cellular clusters within the skin epithelium. These organized lymphocyte clusters are surrounded by keratinocytes expressing a discrete program associated with antigen presentation and antimicrobial defense. Notably, IL-22–mediated keratinocyte-intrinsic MHC class II expression was required for the selective accumulation of commensal-induced IFN-γ, but not IL-17A–producing CD4 + T cells within the skin. Taking these data together, this work uncovers an unexpected role for MHC class II expression by keratinocytes in the control of homeostatic type 1 responses to the microbiota. Our findings have important implications for the understanding of the tissue-specific rules governing the dialogue between a host and its microbiota..
关键词：microbiota ; skin ; keratinocyte ; antigen presentation ; Th1