文章基本信息

标题：Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake
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作者：Jonathan Gaucher ; Kenichiro Kinouchi ; Nicholas Ceglia 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2019
卷号：116
期号：50
页码：25250-25259
DOI：10.1073/pnas.1911189116
出版社：The National Academy of Sciences of the United States of America
摘要：Binge drinking and chronic exposure to ethanol contribute to alcoholic liver diseases (ALDs). A potential link between ALDs and circadian disruption has been observed, though how different patterns of alcohol consumption differentially impact hepatic circadian metabolism remains virtually unexplored. Using acute versus chronic ethanol feeding, we reveal differential reprogramming of the circadian transcriptome in the liver. Specifically, rewiring of diurnal SREBP transcriptional pathway leads to distinct hepatic signatures in acetyl-CoA metabolism that are translated into the subcellular patterns of protein acetylation. Thus, distinct drinking patterns of alcohol dictate differential adaptation of hepatic circadian metabolism..
关键词：alcohol ; circadian ; acetylation ; liver ; metabolism