文章基本信息

标题：LC/Tribrid Orbitrapによる強壮系健康食品中のPhosphodiesterase-5阻害薬および構造類似体の分析
本地全文：下载
作者：坂本美穂 ; 蓑輪佳子 ; 岸本清子等
期刊名称：食品衛生学雑誌
印刷版ISSN：0015-6426
电子版ISSN：1882-1006
出版年度：2019
卷号：60
期号：4
页码：96-107
DOI：10.3358/shokueishi.60.96
出版社：The Food Hygienic Society of Japan
摘要：LC/Tribrid Orbitrap was developed to determine phosphodiesterase-5 （PDE-5） inhibitors and their analogs as adulterants in dietary supplements. High-resolution MS/MS and MS3 spectra of PDE-5 inhibitors and their analogs were obtained by LC/Tribrid Orbitrap using both higher-energy collisional dissociation and collision-induced dissociation. We investigated dietary supplements that claim to enhance men’s sexual performance, and detected PDE-5 inhibitors and their analogs. We also estimated the structures of the PDE-5 inhibitor analogs and the impurities of PDE-5 inhibitors and their analogs in the dietary supplements.
关键词：シルデナフィル;タダラフィル;バルデナフィル;健康食品;液体クロマトグラフ法;質量分析計;sildenafil;tadalafil;vardenafil;dietary supplement;LC;MS