文章基本信息

标题：Design Studies of A High-Performance Onboard Positron Emission Tomography For Integrated Small Animal PET/CT/RT Radiation Research Systems
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作者：Yiping Shao ; Yuncheng Zhong ; Xinyi Cheng 等
期刊名称：Lecture Notes in Engineering and Computer Science
印刷版ISSN：2078-0958
电子版ISSN：2078-0966
出版年度：2018
卷号：2233&2234
页码：731-736
出版社：Newswood and International Association of Engineers
摘要：The overall objective of this research is to design, develop, and evaluate an onboard high-performance Positron Emission Tomography (PET) that will be integrated into an existing CT image-guided small animal precision X-ray radiation therapy system (CT/RT). This new PET/CT/RT will enable streamlined PET/CT biology functional and organ anatomic dual-modality images to guide the therapy, and provide substantially improved beam targeting accuracy and therapy response evaluation. Both simulation and experiment studies were conducted to investigate the detector design with different resolutions, sensitivities, readout methods, and PET system configurations with different image field of view (FOV) and image performance tradeoffs. The results have shown that the 1.0 mm PET uniform image resolution and ~4% system sensitivity can be achieved within a 80 mm trans-axial and 30 mm axial image FOV. A prototype detector that has been developed and evaluated can achieve energy, coincidence timing, and depth-of-interaction resolutions at ~16%, 1.14 ns, and <3.0 mm respectively. In summary, the overall PET detector and system design studies have been successfully conducted for establishing solid technical solutions to develop the PET/CT/RT system.
关键词：Positron Emission Tomography; depth-ofinteraction;; PET/CT image guided radiotherapy; small animal; translational radiation therapy research.