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  • 标题:Ebenamariosides A–D: Triterpene Glucosides and Megastigmanes from the Leaves of Diospyros maritima
  • 本地全文:下载
  • 作者:Susumu Kawakami ; Erika Miura ; Ayaka Nobe
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2019
  • 卷号:67
  • 期号:12
  • 页码:1337-1346
  • DOI:10.1248/cpb.c19-00803
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    The 1-BuOH-soluble fraction of the methanol (MeOH) extract of Diospyros maritima was separated by chromatographic techniques to give three new oleanane-type and one new ursane-type triterpene glucoside, named ebenamariosides A–D (1–4); two megastigmanes were also isolated. The structures of triterpene glucosides was elucidated with extensive investigation by one and two dimensional NMR spectroscopy and the structures were confirmed by partial enzymatic hydrolyses to give the corresponding mono-glucosides and aglycones. The structures of the megastigmanes, including their absolute stereochemistries, were elucidated by spectroscopic evidence and by the modified Mosher’s method. Two megastigmanes were chemically correlated and their absolute structures were unambiguously determined. The cytotoxicity of the triterpene glucosides and their degradation products were assayed. They did not show any significant activity.

  • 关键词:Diospyros maritima;Ebenaceae;ebanamarioside;triterpene glucoside;megastigmane
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