文章基本信息

标题：Quorum Sensing Inhibitors against Chromobacterium violaceum CV026 Derived from an Actinomycete Metabolite Library
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作者：Toshiko Ohta ; Atsushi Fukumoto ; Yohei Iizaka 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2020
卷号：43
期号：1
页码：179-183
DOI：10.1248/bpb.b19-00564
出版社：The Pharmaceutical Society of Japan
摘要：Quorum sensing (QS) is a microbial signaling system that regulates the expression of many virulence genes. Herein, we studied five compounds—No. 1: ( E )-2-methyl-3- (4-nitro-phenyl)-acrylaldehyde; No. 29-2: pimprinine [5-(1 H -indol-3-yl)-2-methyloxazole]; No. 48: (2 E ,4 E )-2-methyl-5-phenyl-2,4-pentadienoic acid; No. 74: (3 E ,5 E )-5-methyl-6-(4-nitrophenyl)-hexa-3,5-dien-2-ol; and No. 130: methyphenazine-1-carboxylate—derived from an actinomycete metabolite library. These compounds were confirmed to be QS inhibitors that reduced violacein production in Chromobacterium violaceum CV026. Additionally, compounds No. 1, No. 74, and No. 130 significantly reduced fluorescent pigment production in Pseudomonas aeruginosa ATCC 27853.
关键词：quorum sensing inhibitor;Pseudomonas aeruginosa;actinomycete metabolite library