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标题：Chronotoxicity of Streptomycin-Induced Renal Injury in Mice
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作者：Hiroki Yoshioka ; Sarah Tominaga ; Yasuro Shinohara 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2020
卷号：43
期号：1
页码：53-58
DOI：10.1248/bpb.b19-00539
出版社：The Pharmaceutical Society of Japan
摘要：The aim of the present study was to investigate the “chronotoxicity” of streptomycin (SM) in relation to its circadian periodicity. Male ICR mice were injected intraperitoneally with SM (780 mg/kg, one shot) one of six time points throughout the day. Mortality was monitored until 14 d after the injection and clearly differed depending on the timing of the injection ( i.e. , mice were more sensitive to injection during the dark phase). Moreover, when mice were administered with non-lethal doses of SM (550 mg/kg, every 24 h for 3 d, in the light phase or dark phase), the levels of nephrotoxicity indicators (blood urea nitrogen and renal levels of malondialdehyde and cyclooxygenase-2) were significantly increased by the injection in the dark phase, but not in the light phase. These results suggested that SM showed clear chronotoxicity. Our current data indicated that chronotoxicology may provide valuable information on the importance of injection timings for evaluations of toxicity and undesirable side effects.
关键词：chronotoxicity;streptomycin;nephrotoxicity;circadian rhythm;side effect