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标题：The Emerging Link between the Hippo Pathway and Non-coding RNA
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作者：Mayuko Shimoda ; Toshiro Moroishi
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2020
卷号：43
期号：1
页码：1-10
DOI：10.1248/bpb.b19-00795
出版社：The Pharmaceutical Society of Japan
摘要：The Hippo intracellular signaling pathway plays a pivotal role in cell fate determination. Although previous studies have identified many components of the Hippo pathway, the whole picture of the Hippo network is just beginning to be delineated. Recent discoveries in the past decade have shed light on a newly discovered signaling network where the Hippo pathway interplays with several types of non-coding RNAs, including microRNAs, long non-coding RNAs and circular RNAs, to mediate diverse biological processes. Those non-coding RNAs communicate with each other to maintain cellular homeostasis. In this review article, we summarize the current and emerging understanding of the roles of non-coding RNAs in the regulation of and by the Hippo pathway.
关键词：Hippo pathway;non-coding RNA;competing endogenous RNA;signal crosstalk;cancer;regeneration