文章基本信息

标题：Determinants of morbidities and mortality in acromegaly
其他标题：Determinants of morbidities and mortality in acromegaly
本地全文：下载
作者：Kasuki, Leandro ; Rocha, Paula da Silva ; Lamback, Elisa Baranski 等
期刊名称：Archives of Endocrinology and Metabolism
印刷版ISSN：2359-3997
出版年度：2019
卷号：63
期号：6
页码：630-637
DOI：10.20945/2359-3997000000193
出版社：Archives of Endocrinology and Metabolism
摘要：ABSTRACT Acromegaly is a systemic disease associated with increased morbidity, presenting cardiovascular, metabolic, respiratory, neoplastic, endocrine, articular and bone complications. Most of these comorbidities can be prevented or delayed with adequate disease treatment and, more recent studies with the use of modern treatments of acromegaly, have shown a change in the severity and prevalence of these complications. In addition, acromegaly is associated with increased mortality, but recent studies (especially those published in the last decade) have shown a different scenario than older studies, with mortality no longer being increased in adequately controlled patients and a change in the main cause of death from cardiovascular disease to malignancy. In this review, we discuss this changing face of acromegaly summarizing current knowledge and evidence on morbimortality of the disease.
关键词：Acromegaly; systemic complications; mortality; cardiovascular disease; cancer.
其他关键词：Acromegaly;systemic complications;mortality;cardiovascular disease;cancer