文章基本信息

标题：New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
其他标题：New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
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作者：List, Edward O. ; Berryman, Darlene E. ; Jensen, Elizabeth A. 等
期刊名称：Archives of Endocrinology and Metabolism
印刷版ISSN：2359-3997
出版年度：2019
卷号：63
期号：6
页码：557-567
DOI：10.20945/2359-3997000000185
出版社：Archives of Endocrinology and Metabolism
摘要：ABSTRACT In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include liver, muscle, fat, brain, bone, heart, intestine, macrophage, pancreatic beta cells, hematopoietic stem cells, and multi-tissue “global”. In this review, we provide a brief history and description of the 21 tissue-specific GHR knockout mouse lines.
关键词：Tissue-specific knockout; GHR; GHRKO; conditional knockout; gene disruption.
其他关键词：Tissue-specific knockout;GHR;GHRKO;conditional knockout;gene disruption