文章基本信息

标题：Protective effect of crocetin from Crocus sativus L. on myocardial ischemia-reperfusion injury in rats
其他标题：Protective effect of crocetin from Crocus sativus L. on myocardial ischemia-reperfusion injury in rats
本地全文：下载
作者：LIU, Chengxiao ; SUN, Erlian ; MENG, Wenjun 等
期刊名称：Food Science and Technology (Campinas)
印刷版ISSN：0101-2061
电子版ISSN：1678-457X
出版年度：2019
卷号：39
页码：595-600
DOI：10.1590/fst.28918
出版社：Sociedade Brasileira de Ciência e Tecnologia de Alimentos
摘要：Abstract This study investigated the protective effect of crocetin from Crocus sativus L. on myocardial ischemia-reperfusion injury (MIRI) in rats. Sixty SD rats were randomly divided into sham-operated, model, and low-, medium- and high-dose crocetin groups. Later 3 groups were intragastrically administrated with 10, 20 and 40 mg/kg crocetin from Crocus sativus L., respectively, for 1 week. On the 8th day, the MIRI model was established in the later 4 groups. The blood biochemical indexes, hemodynamic indexes, myocardial infarct size, myocardial antioxidant indexes and myocardial expressions of B-cell lymphoma-2 (Bcl-2), Bcl-2 associated X protein (Bax), serine/threonine kinase (Akt) and phosphorylated Akt (p-Akt) protein were determined. Results showed that, compared with model group, in high-dose crocetin group the left ventricular systolic pressure, +dp/dtmax and -dp/dtmax, myocardial superoxide dismutase and glutathione peroxidase levels, and myocardial Bcl-2/Bax ratio and p-Akt/Akt ratio were significantly increased, and the left ventricular end diastolic pressure, myocardial infarct size, serum lactate dehydrogenase, creatine kinase-MB, cardiac troponin I, tumor necrosis factor-α, interleukin-1β, interleukin-6 and malondialdehyde levels were significantly decreased (all P < 0.05). In conclusion, crocetin from Crocus sativus L. has protective effects on MIRI in rats.
关键词：crocetin; ischemia-reperfusion injury; Bcl-2; Bax; Akt.
其他关键词：crocetin;ischemia-reperfusion injury;Bcl-2;Bax;Akt