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标题：Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet—A Randomized Controlled Trial in Healthy Participants
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作者：Ann-Kathrin Lederer ,, , Luciana Hannibal , , Manuel Hettich , Sidney Behringer , Ute Spiekerkoetter , Carmen Steinborn , Carsten Gründemann , Amy Marisa Zimmermann-Klemd , Alexander Müller , Thomas Simmet , Michael Schmiech , Andrea Maul-Pavicic , , Yvonne Samstag ; Roman Huber
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：11
页码：1-16
DOI：10.3390/nu11112815
出版社：MDPI Publishing
摘要：Vegans are at an increased risk for certain micronutrient deficiencies, foremost of vitamin B12. Little is known about the short-term effects of dietary change to plant-based nutrition on vitamin B12 metabolism. Systemic biomarkers of vitamin B12 status, namely, serum vitamin B12 and holotranscobalamin, may respond quickly to a reduced intake of vitamin B12. To test this hypothesis, 53 healthy omnivore subjects were randomized to a controlled unsupplemented vegan diet (VD, n = 26) or meat-rich diet (MD, n = 27) for 4 weeks. Vitamin B12 status was examined by measurement of serum vitamin B12, holotranscobalamin (holo-TC), methylmalonic acid (MMA) and total plasma homocysteine (tHcy). Holo-TC decreased significantly in the VD compared to the MD group after four weeks of intervention, whereas metabolites MMA and tHcy were unaffected. Body weight remained stable in both groups. VD intervention led to a significant reduction of cholesterol intake, and adequate profiles of nutrient and micronutrient status. Lower intake of vitamin B12 was observed in VD, which was mirrored by a lower concentration of serum vitamin B12 and reduced holo-TC after 4 weeks. Plasma holo-TC may be a fast-responding biomarker to monitor adequate supply of vitamin B12 in plant-based individuals.
关键词：vegan nutrition; holotranscobalamin; fatty acids; vitamin B₁₂; micronutrient vegan nutrition ; holotranscobalamin ; fatty acids ; vitamin B₁₂ ; micronutrient