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标题：Use of Oral Prednisolone and a 3-Phase Bone Scintigraphy in Patients with Complex Regional Pain Syndrome Type I
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作者：Seunghun Park ; Hyun-Jun Kim ; Dong Kyu Kim 等
期刊名称：Healthcare
电子版ISSN：2227-9032
出版年度：2020
卷号：8
期号：1
DOI：10.3390/healthcare8010016
出版社：MDPI Publishing
摘要：To compare the treatment effects of a high-dose and low-dose oral steroid regimen based on changes in the radioisotope uptake ratio (RUR) observed from three-phase bone scintigraphy (TPBS) in patients with complex regional pain syndrome type I (CRPS I), we retrospectively analyzed data of 34 patients with CRPS I from traumatic brain injury and stroke. Depending on the dose of steroid administered, patients were divided into high-dose (n = 14) and low-dose steroid groups (n = 20). We compared the severity scores, Kozin’s classification scores, and RUR observed from TPBS between the two groups. There were significant changes in the severity scores and Kozin’s classification between the baseline and 2 weeks from baseline (p 0.05). There were no treatment-emergent adverse events (TEAEs) such as blood pressure elevation, impaired glycemic control, or gastrointestinal disturbances. Our results indicate that the efficacy profile of a low-dose oral steroid regimen is comparable to that of a high-dose regimen in alleviating symptoms in CRPS I patients. However, additional prospective, large-scale, multi-center studies are warranted to confirm our results.
关键词：complex regional pain syndromes; steroids; radionuclide imaging; high dose; low dose complex regional pain syndromes ; steroids ; radionuclide imaging ; high dose ; low dose