文章基本信息

标题：Chitosan composites nerve conduits
本地全文：下载
作者：Yifan Chen
期刊名称：E3S Web of Conferences
印刷版ISSN：2267-1242
电子版ISSN：2267-1242
出版年度：2019
卷号：131
页码：1-6
DOI：10.1051/e3sconf/201913101006
出版社：EDP Sciences
摘要：Traumatic nerve defect affected over 200, 00 people in the US. As it affected so many people, autografts as the golden standard solution have their limitations. Nerve conduits is a new method and the materials for conduits establishing contain biological materials, synthetic materials and composite materials. Among these categories, composite conduits appear better regeneration ability. Also, chitosan demonstrated have the ability to help nerve regeneration. Thus, chitosan composite may be a good choice in the future. This article compares six kinds of chitosan composite: Laminin-chitosan-PLGA, Chitosan-Zinc Oxide Nanocomposite, PCL/Chitosan/Verapamil, Chitosan/ hyaluronic acid conduit, Chitosan/simvastatin/Pluronic F-127 hydrogel and Chitin/ Carboxymethyl (CM)-chitosan by conduit structure, establishment method, sciatic functional index (SFI), electrophysiology and histology data. This article concludes that chitosan-drug-drug delivery system showed the best recovery result.
其他摘要：Traumatic nerve defect affected over 200, 00 people in the US. As it affected so many people, autografts as the golden standard solution have their limitations. Nerve conduits is a new method and the materials for conduits establishing contain biological materials, synthetic materials and composite materials. Among these categories, composite conduits appear better regeneration ability. Also, chitosan demonstrated have the ability to help nerve regeneration. Thus, chitosan composite may be a good choice in the future. This article compares six kinds of chitosan composite: Laminin-chitosan-PLGA, Chitosan-Zinc Oxide Nanocomposite, PCL/Chitosan/Verapamil, Chitosan/ hyaluronic acid conduit, Chitosan/simvastatin/Pluronic F-127 hydrogel and Chitin/ Carboxymethyl (CM)-chitosan by conduit structure, establishment method, sciatic functional index (SFI), electrophysiology and histology data. This article concludes that chitosan-drug-drug delivery system showed the best recovery result.