文章基本信息

标题：Gene Expression of OCT4 and NANOG Correlated with Advanced Stage and Worse Survival in Breast Cancer Patients
本地全文：下载
作者：Fawziya A. R Ibrahim ; Shaymaa E. El Feky ; Kadhim K. Kadhim 等
期刊名称：Journal of Cancer Research and Treatment
印刷版ISSN：2374-1996
电子版ISSN：2374-2003
出版年度：2019
卷号：7
期号：2
页码：36-43
DOI：10.12691/jcrt-7-2-1
出版社：Science and Education Publishing
摘要：The present study aimed to show the correlation between expression of cancer stem cell markers (OCT4 and NANOG) with both clinicopathological features and survival of breast cancer (BC) patients. Methods: The gene expressions of OCT4 and NANOG were quantified using real time polymerase chain reaction, clinicopathological data have been collected from patients' data records and patients were followed-up with a median duration of 110 months. Results: OCT4 (pConclusions: From these findings, it may be concluded that the upregulated expressions of OCT4 and NANOG were associated with worse clinical outcome and could be used as predictive markers for poor DFS in BC patients.
关键词：breast cancer; stemness markers; Oct-4; NANOG; prognosis