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  • 标题:On the origin of a pathogenic HERV-W envelope protein present in multiple sclerosis lesions
  • 本地全文:下载
  • 作者:Achmad Hidayat Sutawijaya ; Sabrina O. Sihombing
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2019
  • 卷号:116
  • 期号:40
  • 页码:19791-19792
  • DOI:10.1073/pnas.1911703116
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:We read with great interest the recent article by Kremer et al. showing that an envelope (ENV) protein encoded by human endogenous retrovirus type W (HERV-W) is present in myeloid cells in multiple sclerosis (MS) lesions, as detected by mouse monoclonal antibody GN-mAB_03 (3B2H4) directed against HERV-W ENV (1). Furthermore, microglia stimulated with a recombinant HERV-W ENV protein (as encoded by GenBank sequence AF331500) damaged myelinated axons, suggesting that HERV-W ENV may contribute to neurodegeneration in MS, consistent with a recent phase IIb clinical study demonstrating neuroprotective effects of a recombinant anti-HERV-W ENV antibody (GNbAC1) in MS (1). However, despite accumulating evidence for a pathogenic role of HERV-W ENV in MS, the nature of the actual protein is unclear. There are at least 13 HERV-W loci with full-length env genes in the human genome (2), only one of which, in human chromosome 7q21.2, has an uninterrupted open reading frame (ORF).
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