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  • 标题:Effect of immune-enhancing enteral nutrition formula enriched with plant-derived n-3 fatty acids on natural killer cell activity in rehabilitation patients
  • 本地全文:下载
  • 作者:Silvia Viana ; Cassio Arruda Boechat ; Vicente Arruda Câmara Rodrigues
  • 期刊名称:Nutrition Research and Practice
  • 印刷版ISSN:1976-1457
  • 出版年度:2019
  • 卷号:13
  • 期号:5
  • 页码:384-392
  • DOI:10.4162/nrp.2019.13.5.384
  • 出版社:KoreaMed Synapse
  • 摘要:BACKGROUND/OBJECTIVES

    Enteral nutrition formulas with immune-enhancing nutrients, such as n -3 fatty acids, may manage patients' nutritional status and pathophysiological processes. The aim of our study was to investigate natural killer (NK) cell activity alterations and related cytokine changes resulting from feeding with soybean oil-containing enteral nutrition formula (control group) and plant-derived n -3 fatty acid-enriched enteral nutrition formula. SUBJECTS/METHODS

    Subjects participated for 14 consecutive days and consumed enteral formula containing canola and flaxseed oil (n3EN, test group) in nonsurgical patients hospitalized for rehabilitation. Blood samples were collected on the first day and 14 days after the consumption of each formula daily, and anthropometric parameters were collected. Hematology and biochemical values were analyzed, and NK cell activities and serum cytokine concentration were measured. A total of sixty subjects were included in the analysis, excluding dropouts. RESULTS

    No significant differences were found in biochemical parameters. The n3EN group's NK cell activities at effector:tumor cell ratios of 10:1, 5:1, 2.5:1 and 0.625:1 were significantly higher than those of the control group after two weeks ( P < 0.05). However, there were no statistically significant differences in serum cytokine interleukin (IL)-12, interferon-γ, IL-1β, IL-6 and tumor necrosis factor-α values between the two groups. CONCLUSIONS

    In conclusion, this study elucidates the beneficial effects of plant-derived n -3 fatty acid supplementation in enteral formula on NK cell activity.

  • 关键词:Immune system; Enteral nutrition; canola oil; flaxseed oil; Natural killer cell
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