文章基本信息

标题：The Comparison of the Analgesic Effect of Intravenous Acetaminophen with Fentanyl in Thoracic and Abdominal Surgeries of Newborns
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作者：Kamran Dehghan ; Masoumeh Ghalizadeh ; Ali Aghayar Macooie 等
期刊名称：International Journal of Pediatrics
印刷版ISSN：2345-5047
电子版ISSN：2345-5055
出版年度：2019
卷号：7
期号：7
页码：9773-9781
DOI：10.22038/ijp.2019.39812.3388
出版社：Mashhad University of Medical Sciences
摘要： Background
The use of opioid drugs for controlling pain during and after surgery is a common but complicated procedure in neonatal anesthesia. This study compared the analgesic effect of acetaminophen with fentanyl after abdominal and chest surgery in Iranian newborns.
Materials and Methods
This randomized, double-blind clinical trial was conducted in two hospitals; in the NICU of Shahid Motahari hospital in Urmia and Namazi hospital in Shiraz, Iran. Sixty-six patients were randomized sequentially and assigned in two groups. One group of patients received acetaminophen dose of 10 mg/kg every six hours, and another group received fentanyl 6 µg/Kg every six hours for 48 hours (9 doses). For all patients, pain was assessed using the "Neonatal Infant Pain Scale (NIPS)" at first time, 6, 12, 18, 24, 30, 36, 42 and 48 hours (9 measurements). If necessary, fentanyl 1 µg/Kg was injected to the patients. Finally, all the information was recorded and analyzed using SPSS software (version 21.0).
Results
The mean age of the fentanyl group was 16.79 ± 15.57 days and 16.67 ± 15.77 days in the acetaminophen group (P>0.05). The mean weight in the fentanyl group was 3460 ± 737 gr and in the acetaminophen group was 3228.548 ± 32.28 gr (P>0.05). Results showed that the mean scores of pain in all periods of time were not significantly different between the two groups (P>0.05). No drug complications were seen in the acetaminophen group.
Conclusion
Based on the results, mean score of pain in fentanyl and acetaminophen groups was not statistically significant. Acetaminophen did not control pain as well as fentanyl in neonatal surgeries.
关键词：Acetaminophen; Analgesia; Fentanyl; Newborn; Surgery