文章基本信息

标题：Ketogenic Diet and Skeletal Muscle Hypertrophy: a Frenemy Relationship?
本地全文：下载
作者：Antonio Paoli ; Pasqualina Cancellara ; Pierluigi Pompei 等
期刊名称：Journal of Human Kinetics
印刷版ISSN：1640-5544
电子版ISSN：1899-7562
出版年度：2019
卷号：68
期号：1
页码：233-247
DOI：10.2478/hukin-2019-0071
出版社：Walter de Gruyter GmbH
摘要：Ketogenic diet (KD) is a nutritional regimen characterized by a high-fat and an adequate protein content and a very low carbohydrate level (less than 20 g per day or 5% of total daily energy intake). The insufficient level of carbohydrates forces the body to primarily use fat instead of sugar as a fuel source. Due to its characteristic, KD has often been used to treat metabolic disorders, obesity, cardiovascular disease, and type 2 diabetes. Skeletal muscle constitutes 40% of total body mass and is one of the major sites of glucose disposal. KD is a well-defined approach to induce weight loss, with its role in muscle adaptation and muscle hypertrophy less understood. Considering this lack of knowledge, the aim of this review was to examine the scientific evidence about the effects of KD on muscle hypertrophy. We first described the mechanisms of muscle hypertrophy per se, and secondly, we discussed the characteristics and the metabolic function of KD. Ultimately, we provided the potential mechanism that could explain the influence of KD on skeletal muscle hypertrophy.
关键词：ketogenic diet ; skeletal muscle hypertrophy ; resistance training ; signaling ; muscle protein synthesis