文章基本信息

标题：Reply to Velavan et al.: Polymorphisms of pfcoronin in natural populations: Implications for functional significance
本地全文：下载
作者：Aabha I. Sharma ; Allison R. Demas ; Daniel L. Hartl 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2019
卷号：116
期号：26
页码：12613-12614
DOI：10.1073/pnas.1907920116
出版社：The National Academy of Sciences of the United States of America
摘要：Velavan et al. (1) describe work that they have carried out based on our recent PNAS publication, “Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility” (2). Among 297 patient samples from 4 countries in Africa, they found 12 polymorphic amino acid sites in Pf Coronin, 7 observed only among 48 parasites from the Congo (1). These findings are consistent with results reported in the Pf3k database (https://www.malariagen.net/projects/p-falciparum-communityproject), which we referenced in our original publication. The amino acid replacements of Pf Coronin that we found to be .